Hopefully Amazon learned a lot from the Fallout show. Never ever ever pick a very specific area/time/character and try to recreate it. Thats what all the other shows did and failed. 40k lore is so expansive they can do exactly the same thing as Fallout...just pick a random place, make a new story entirely with new characters.
My fear is, like so many shows before, they will focus on a well known established character and butcher it.